Activation of the AGE/RAGE system in the brains of rats and in SH-SY5Y cells exposed to high level of fluoride might connect to oxidative stress.

@article{Zhang2015ActivationOT,
  title={Activation of the AGE/RAGE system in the brains of rats and in SH-SY5Y cells exposed to high level of fluoride might connect to oxidative stress.},
  author={Kai-lin Zhang and Di-dong Lou and Zhi-Zhong Guan},
  journal={Neurotoxicology and teratology},
  year={2015},
  volume={48},
  pages={49-55}
}
To explore the mechanisms by which chronic fluorosis damages the brain, we determined the levels of the advanced glycation end-products (AGEs), the receptor for AGE (RAGE), NADPH oxidase-2 (NOX2), reactive oxygen species (ROS) and malondialdehyde (MDA) in the brains of rats and/or SH-SY5Y cells exposed to different levels of sodium fluoride (5 or 50 ppm in the drinking water for 3 or 6 months and in the incubation medium for as long as 48 h, respectively). The levels of AGEs, RAGE and NOX2… CONTINUE READING
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