Activation of the 2-5OAS/RNase L pathway in CVB1 or HAV/18f infected FRhK-4 cells does not require induction of OAS1 or OAS2 expression.

Abstract

The latent, constitutively expressed protein RNase L is activated in coxsackievirus and HAV strain 18f infected FRhK-4 cells. Endogenous oligoadenylate synthetase (OAS) from uninfected and virus infected cell extracts synthesizes active forms of the triphosphorylated 2-5A oligomer (the only known activator of RNase L) in vitro and endogenous 2-5A is… (More)
DOI: 10.1016/j.virol.2009.03.014

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@article{Kulka2009ActivationOT, title={Activation of the 2-5OAS/RNase L pathway in CVB1 or HAV/18f infected FRhK-4 cells does not require induction of OAS1 or OAS2 expression.}, author={Michael Kulka and Mona S. Calvo and Diana T Ngo and Samantha Q. Wales and Biswendu B. Goswami}, journal={Virology}, year={2009}, volume={388 1}, pages={169-84} }