Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons.

@article{Takashima1998ActivationOT,
  title={Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons.},
  author={Akihiko Takashima and Takeshi Honda and Kaori Yasutake and Germaine Michel and Ohoshi Murayama and Miyuki Murayama and Koichi Ishiguro and Haruyasu Yamaguchi},
  journal={Neuroscience research},
  year={1998},
  volume={31 4},
  pages={317-23}
}
According to the amyloid hypothesis for the pathogenesis of Alzheimer's disease (AD), amyloid beta peptide (Abeta) directly affects neurons, leading to neurodegeneration and tau phosphorylation, followed by the production of paired helical filaments (PHF) in neurofibrillary tangles (NFT). To analyze the relationship between the phosphorylation sites of tau and the activation of kinases in response to Abeta, we treated cultured rat hippocampal neurons with a peptide fragment of Abeta, Abeta(25… CONTINUE READING

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