Activation of targeted necrosis by a p53 peptide: a novel death pathway that circumvents apoptotic resistance.

@article{Dinnen2007ActivationOT,
  title={Activation of targeted necrosis by a p53 peptide: a novel death pathway that circumvents apoptotic resistance.},
  author={Richard D. Dinnen and Lisa Drew and Daniel Peter Petrylak and Yuehua Mao and Nicholas D. Cassai and Joseph Szmulewicz and Paul Wesley Brandt-Rauf and Robert Fine},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 37},
  pages={26675-86}
}
Cancer cells escape apoptosis by intrinsic or acquired mechanisms of drug resistance. An alternative strategy to circumvent resistance to apoptosis could be through redirection into other death pathways, such as necrosis. However, necrosis is a nonspecific, nontargeted process resulting in cell lysis and inflammation of both cancer and normal cells and is therefore not a viable alternative. Here, we report that a C-terminal peptide of p53, called p53p-Ant, induced targeted necrosis only in… CONTINUE READING