Activation of synaptic NMDA receptors by action potential-dependent release of transmitter during hypoxia impairs recovery of synaptic transmission on reoxygenation.

@article{Sebastio2001ActivationOS,
  title={Activation of synaptic NMDA receptors by action potential-dependent release of transmitter during hypoxia impairs recovery of synaptic transmission on reoxygenation.},
  author={Ana M. Sebasti{\~a}o and Alexandre de Mendonça and Tiago Nunes Moreira and Joaquim Alexandre Ribeiro},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 21},
  pages={8564-71}
}
Increased levels of glutamate and the subsequent activation of NMDA receptors are responsible for neuronal damage that occurs after an ischemic or hypoxic episode. In the present work, we investigated the relative contribution of presynaptic and postsynaptic blockade of synaptic transmission, as well as of blockade of NMDA receptors, for the facilitation of recovery of synaptic transmission in the CA1 area of rat hippocampal slices exposed to prolonged (90 min) hypoxia. During hypoxia, there… CONTINUE READING