Activation of surrogate death receptor signaling triggers peroxynitrite-dependent execution of cisplatin-resistant cancer cells

@article{Seah2015ActivationOS,
  title={Activation of surrogate death receptor signaling triggers peroxynitrite-dependent execution of cisplatin-resistant cancer cells},
  author={Shirley Gek‐Kheng Seah and Ivan Cherh Chiet Low and Jayshree L. Hirpara and Karishma Sachaphibulkij and Guido Kroemer and Catherine Brenner and Shazib Pervaiz},
  journal={Cell Death and Disease},
  year={2015},
  volume={6},
  pages={e1926-}
}
Platinum-based drugs remain as the cornerstone of cancer chemotherapy; however, development of multidrug resistance presents a therapeutic challenge. This study aims at understanding the molecular mechanisms underlying resistance to cisplatin and unraveling surrogate signaling networks that could revert sensitivity to apoptosis stimuli. We made use of three different sets of cell lines, A549 and H2030 non-small-cell lung cancer (NSCLC) and A2780 ovarian cancer cells and their cisplatin… CONTINUE READING