Activation of supraspinal NMDA receptors by both D-serine alone or in combination with morphine leads to the potentiation of antinociception in tail-flick test of rats.

@article{Yoshikawa2007ActivationOS,
  title={Activation of supraspinal NMDA receptors by both D-serine alone or in combination with morphine leads to the potentiation of antinociception in tail-flick test of rats.},
  author={M. Yoshikawa and Kenji Ito and Miho Maeda and K. Akahori and Shigeru Takahashi and X. Jin and M. Matsuda and Toshiyasu Suzuki and T. Oka and Hiroyuki Kobayashi and A. Hashimoto},
  journal={European journal of pharmacology},
  year={2007},
  volume={565 1-3},
  pages={
          89-97
        }
}
Although there is a variety of information concerning the effects of the N-methyl-D-aspartate (NMDA) receptor on opioid-induced antinociception at the spinal level, little is known about the effects at the supraspinal level. To clarify the role of the NMDA receptor on the morphine-induced antinociception at the supraspinal level, we investigated the effects of the intracerebroventricular (i.c.v.) administration of D-serine, a selective agonist for the glycine site of the NMDA receptors, alone… Expand
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