Activation of stress-related hypothalamic neuropeptide gene expression during morphine withdrawal.

@article{Nuez2007ActivationOS,
  title={Activation of stress-related hypothalamic neuropeptide gene expression during morphine withdrawal.},
  author={Cristina Nu{\~n}ez and Anna F{\"o}ldes and Mar{\'i}a Luisa Laorden and Mar{\'i}a Victoria Milan{\'e}s and Krisztina Kov{\'a}cs},
  journal={Journal of neurochemistry},
  year={2007},
  volume={101 4},
  pages={1060-71}
}
Morphine withdrawal results in serious affective and somatic symptoms including activation of the hypothalamo-pituitary-adrenocortical (HPA) axis. To reveal secretory, activational and transcriptional changes in the hypothalamus of morphine-dependent rats during naloxone precipitated opioid withdrawal, we measured corticosterone secretion, c-Fos induction and heteronuclear (hn)RNA levels of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) in naïve and morphine dependent… CONTINUE READING