Activation of stress-activated protein kinases correlates with neurite outgrowth induced by protease inhibition in PC12 cells.

@article{Giasson1999ActivationOS,
  title={Activation of stress-activated protein kinases correlates with neurite outgrowth induced by protease inhibition in PC12 cells.},
  author={Benoit I Giasson and Wendy Bruening and Heather D. Durham and Walter E. Mushynski},
  journal={Journal of neurochemistry},
  year={1999},
  volume={72 3},
  pages={
          1081-7
        }
}
PC12 cells are well characterized for their ability to differentiate into neuronal-like cells when challenged with nerve growth factor. It has been reported that the calpain and proteasome inhibitor N-acetyl-Leu-Leu-norleucinal (CI) is also able to induce neurite outgrowth in PC12 cells. In this study, we report that the inhibitor of proteasomal chymotrypsin-like activity, carbobenzoxy-Ile-Glu-(O-tert-butyl)-Ala-Leu-aldehyde (PSI), can also induce differentiation of PC12 cells. Induction of… CONTINUE READING
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