Activation of spinal kainate receptors after inflammation: behavioral hyperalgesia and subunit gene expression.

@article{Guo2002ActivationOS,
  title={Activation of spinal kainate receptors after inflammation: behavioral hyperalgesia and subunit gene expression.},
  author={Wei Guo and Shiping Zou and Michael J. Tal and Ke Ren},
  journal={European journal of pharmacology},
  year={2002},
  volume={452 3},
  pages={309-18}
}
We determined whether neural responses to inflammation and hyperalgesia involve activation of kainate receptors, a subgroup of glutamate receptors. Inflammation was introduced into the hind paw by intraplantar injection of complete Freund's adjuvant. The inflammation-induced thermal hyperalgesia was attenuated by intrathecal administration of a non-selective alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptor antagonist, 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f… CONTINUE READING

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