Activation of specific neuronal networks leads to different seizure onset types.

@article{Shiri2016ActivationOS,
  title={Activation of specific neuronal networks leads to different seizure onset types.},
  author={Zahra Shiri and Fr{\'e}d{\'e}ric Manseau and Maxime L{\'e}vesque and Sylvain Williams and Massimo Avoli},
  journal={Annals of neurology},
  year={2016},
  volume={79 3},
  pages={354-65}
}
OBJECTIVE Ictal events occurring in temporal lobe epilepsy patients and in experimental models mimicking this neurological disorder can be classified, based on their onset pattern, into low-voltage, fast versus hypersynchronous onset seizures. It has been suggested that the low-voltage, fast onset pattern is mainly contributed by interneuronal (γ-aminobutyric acidergic) signaling, whereas the hypersynchronous onset involves the activation of principal (glutamatergic) cells. METHODS Here, we… CONTINUE READING
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