Activation of simian virus 40 promoter by HTLV-I Tax protein: role of NF-kappaB and CBP.

@article{TabakinFix2004ActivationOS,
  title={Activation of simian virus 40 promoter by HTLV-I Tax protein: role of NF-kappaB and CBP.},
  author={Yulia Tabakin-Fix and Mahmoud M Huleihel and M. Aboud},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={318 4},
  pages={1052-6}
}
HTLV-I is implicated with adult T-cell leukemia and certain other clinical disorders. The viral Tax protein is regarded as a key element in HTLV-I pathogenicity due to its ability to activate a wide variety of cellular regulatory factors. As such, Tax may likely activate also latent infection of certain other pathogenic viruses whose expression is modulated by cellular transcription factors. Therefore, investigation of Tax effect on the expression of these viruses is of particular clinical… CONTINUE READING