Activation of signaling pathways and stress-response genes in an experimental model of retinal detachment.

@article{Zacks2006ActivationOS,
  title={Activation of signaling pathways and stress-response genes in an experimental model of retinal detachment.},
  author={David N. Zacks and Ying Han and Yong Zeng and Anand Swaroop},
  journal={Investigative ophthalmology & visual science},
  year={2006},
  volume={47 4},
  pages={1691-5}
}
PURPOSE Despite the high metabolic demands of the neural retina, its detachment from the retinal pigment epithelium does not lead to immediate death for most of the cells. This study was undertaken to test the hypothesis that intrinsic protective mechanisms are activated in the neural retina during early stages of retinal detachment. METHODS Retinal detachments were created in Brown Norway rats by injection of 1% hyaluronic acid into the subretinal space. Gene expression profiles of retinas… CONTINUE READING
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