Activation of serotonin (5-HT)1A receptors inhibits amphetamine sensitization in mice.

@article{Przegaliski2000ActivationOS,
  title={Activation of serotonin (5-HT)1A receptors inhibits amphetamine sensitization in mice.},
  author={Edmund Przegaliński and Joanna Siwanowicz and Leokadia Baran and Małgorzata Filip},
  journal={Life sciences},
  year={2000},
  volume={66 11},
  pages={1011-9}
}
The effects of serotonin (5-HT)1A drugs on the development and expression of sensitization to the locomotor effect of amphetamine (AMPH) were studied in mice. 8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a 5-HT1A agonist, dose-dependently reduced the expression of AMPH (2.5 mg/kg)-induced sensitization. The latter inhibitory effect of 8-OH-DPAT was reversed by (S)-N-tert-butyl-3-(4-(2-methoxyphenyl)piperazin-1-yl)-2-phenyl propamine (WAY 100135), a 5-HT1A antagonist. WAY 100135 given… CONTINUE READING

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