Activation of serine/threonine protein phosphatase-1 is required for ceramide-induced survival of sympathetic neurons.

Abstract

In sympathetic neurons, C6-ceramide, as well as endogenous ceramides, blocks apoptosis elicited by NGF (nerve growth factor) deprivation. The mechanism(s) involved in ceramide-induced neuronal survival are poorly understood. Few direct targets for the diverse cellular effects of ceramide have been identified. Amongst those proposed is PP-1c, the catalytic… (More)

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@article{Plummer2005ActivationOS, title={Activation of serine/threonine protein phosphatase-1 is required for ceramide-induced survival of sympathetic neurons.}, author={Greg Plummer and Kathleen R Perreault and Charles B Holmes and Elena I Posse de Chaves}, journal={The Biochemical journal}, year={2005}, volume={385 Pt 3}, pages={685-93} }