Activation of rho is involved in the mechanism of hydrogen-peroxide-induced lung edema in isolated perfused rabbit lung.

@article{Chiba2001ActivationOR,
  title={Activation of rho is involved in the mechanism of hydrogen-peroxide-induced lung edema in isolated perfused rabbit lung.},
  author={Yoshihiko Chiba and Yoshiki Ishii and Soichiro Kitamura and Yukihiko Sugiyama},
  journal={Microvascular research},
  year={2001},
  volume={62 2},
  pages={
          164-71
        }
}
Acute lung injury is attributed primarily to increased vascular permeability caused by reactive oxygen species derived from neutrophils, such as hydrogen peroxide (H2O2). Increased permeability is accompanied by the contraction and cytoskeleton reorganization of endothelial cells, resulting in intercellular gap formation. The Rho family of Ras-like GTPases is implicated in the regulation of the cytoskeleton and cell contraction. We examined the role of Rho in H2O2-induced pulmonary edema with… CONTINUE READING
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