Activation of retinoic acid signalling after sciatic nerve injury: up-regulation of cellular retinoid binding proteins.

@article{Zhelyaznik2003ActivationOR,
  title={Activation of retinoic acid signalling after sciatic nerve injury: up-regulation of cellular retinoid binding proteins.},
  author={Nina Zhelyaznik and Kirsten Schrage and Peter McCaffery and J. E. Vander Mey},
  journal={The European journal of neuroscience},
  year={2003},
  volume={18 5},
  pages={1033-40}
}
In mammalian peripheral nerves a crush lesion causes interactions between injured neurons, Schwann cells and haematogenous macrophages that can lead to successful axonal regeneration. We suggest that the transcriptional activator retinoic acid (RA), takes part in gene regulation after peripheral nerve injury and that RA signalling is activated via the cellular retinoic acid binding protein (CRABP)-II and cellular retinol binding protein (CRBP)-I. With RT-PCR and immunoblotting all necessary… CONTINUE READING
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