Activation of renin-angiotensin system induces osteoporosis independently of hypertension.

  title={Activation of renin-angiotensin system induces osteoporosis independently of hypertension.},
  author={Yutaro Asaba and Masako Ito and Toshio Fumoto and Ken Watanabe and Ryoji Fukuhara and Sunao Takeshita and Yuji Nimura and Junji Ishida and Akiyoshi Fukamizu and Kyoji Ikeda},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  volume={24 2},
Hypertension and osteoporosis are two major age-related disorders; however, the underlying molecular mechanism for this comorbidity is not known. The renin-angiotensin system (RAS) plays a central role in the control of blood pressure and has been an important target of antihypertensive drugs. Using a chimeric RAS model of transgenic THM (Tsukuba hypertensive mouse) expressing both the human renin and human angiotensinogen genes, we showed in this study that activation of RAS induces high… CONTINUE READING


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