Activation of recombinant NR1/NR2C NMDA receptors.

  title={Activation of recombinant NR1/NR2C NMDA receptors.},
  author={Shashank Manohar Dravid and Anand Prakash and Stephen F Traynelis},
  journal={The Journal of physiology},
  volume={586 18},
The N-methyl-d-aspartate (NMDA) subtype of ionotropic glutamate receptors comprises both NR1 and NR2 subunits, and plays numerous roles in both physiological and pathophysiological processes in the central nervous system (CNS). NR2C-containing NMDA receptors are most abundant in cerebellum, thalamus and olfactory bulb, and are also expressed in oligodendrocytes and hippocampal interneurons. We have used patch clamp recording to explore the activation properties of recombinant NR1/NR2C receptors… CONTINUE READING