Activation of receptor tyrosine kinases promotes gene transfection in rat neuronal PC12 cells by cationic liposomes

@article{Noguchi2002ActivationOR,
  title={Activation of receptor tyrosine kinases promotes gene transfection in rat neuronal PC12 cells by cationic liposomes},
  author={Ari Noguchi and Naohide Hirashima and Tadahide Furuno and Mamoru Nakanishi},
  journal={Neuroscience Letters},
  year={2002},
  volume={325},
  pages={29-32}
}
Cationic liposomes are commonly used to introduce foreign genes to the target cells. However, the methods are not applicable to several types of cells such as neuronal cells. We introduced the luciferase gene to the neuronal pheochromocytoma-12 (PC12) cells by cationic liposomes with a cationic cholesterol derivative (I) or 3- beta - [N - (N',N' - dimethylaminoethane) - carbamoyl]- cholesterol (DC - Chol). Efficiency of gene transfection into undifferentiated naive PC12 cells was extremely… 
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