Activation of rat T lymphocytes by anti-CD2 monoclonal antibodies

  title={Activation of rat T lymphocytes by anti-CD2 monoclonal antibodies},
  author={S. James Clark and Debbie A. Law and David J. Paterson and Michael J. Puklavec and Alan F. Williams},
  journal={The Journal of Experimental Medicine},
  pages={1861 - 1872}
Rat T cells and thymocytes were induced to proliferate by a pair of mAbs, MRC OX-54 and MRC OX-55, directed against rat CD2. Accessory cells were required but their role was not simply for crosslinking of the two mAbs, as neither MRC OX-54 nor MRC OX-55 alone, in the presence of a crosslinking second antibody, caused T cell mitogenesis. Nor could the… CONTINUE READING