Activation of rapid oestrogen signalling in aggressive human breast cancers

  title={Activation of rapid oestrogen signalling in aggressive human breast cancers},
  author={Coralie Poulard and Isabelle 6 Treilleux and Emilie Lavergne and Katia Bouchekioua-Bouzaghou and Sophie Goddard-L{\'e}on and Sylvie Chabaud and Olivier Tr{\'e}dan and Laura Corbo and Muriel Le Romancer},
  booktitle={EMBO molecular medicine},
Oestrogen receptors can mediate rapid activation of cytoplasmic signalling cascades by recruiting Src and PI3K. However, the involvement of this pathway in breast cancer remains poorly defined. We have previously shown that methylation of ERα is required for the formation of the ERα/Src/PI3K complex and that ERα is hypermethylated in a subset of breast cancers. Here, we used Proximity Ligation Assay to demonstrate that this complex is present in the cytoplasm of breast cancer cell lines as well… CONTINUE READING
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