Activation of rabbit liver fructose diphosphatase by coenzyme A and acyl carrier protein.

@article{Nakashima1969ActivationOR,
  title={Activation of rabbit liver fructose diphosphatase by coenzyme A and acyl carrier protein.},
  author={Karin Nakashima and Sandro Pontremoli and Bernard L. Horecker},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1969},
  volume={64 3},
  pages={947-51}
}
The catalytic activity of rabbit liver fructose diphosphatase is enhanced more than fourfold by treatment with coenzyme A or acyl carrier protein. Other sulfhydryl compounds, such as glutathione or cysteine, are without effect. Activation is reversed by reduced glutathione or cysteine, indicating that the enzyme and activator are linked by disulfide bridges. The activated enzyme derivative can be formed by a disulfide exchange reaction at alkaline pH or by an oxidation reaction which proceeds… CONTINUE READING