Activation of pyramidal cells in rat medial prefrontal cortex projecting to ventral tegmental area by a 5-HT1A receptor agonist

@article{DiazMataix2006ActivationOP,
  title={Activation of pyramidal cells in rat medial prefrontal cortex projecting to ventral tegmental area by a 5-HT1A receptor agonist},
  author={Llorenç Díaz-Mataix and Francesc Casa{\~n}as Artigas and Pau Celada},
  journal={European Neuropsychopharmacology},
  year={2006},
  volume={16},
  pages={288-296}
}

5-HT1A receptor agonists enhance pyramidal cell firing in prefrontal cortex through a preferential action on GABA interneurons.

The present data suggest a preferential action of (±)8-OH-DPAT on 5-HT1AR in GABAergic interneurons results in pyramidal disinhibition and subsequent downstream excitations of subcortical structures reciprocally connected with PFC, such as midbrain dopaminergic neurons.

Glutamatergic neurons of rat medial prefrontal cortex innervating the ventral tegmental area are positive for serotonin 5-HT1A receptor protein.

The results indicate that the drugs operating via serotonin 5-HT1A receptors in the MPC, might control from this level the release of glutamate in the VTA and restore function of glutamate neurotransmission, whose dysfunction is observed for example in schizophrenia.

Involvement of 5-HT1A Receptors in Prefrontal Cortex in the Modulation of Dopaminergic Activity: Role in Atypical Antipsychotic Action

The results suggest that the activation of mPFC 5-HT1A receptors enhances the activity of VTA DA neurons and mesocortical DA release, which may be involved in the elevation of extracellular DA produced by atypical antipsychotics.

Serotonin modulation of cortical neurons and networks

In vitro and in vivo studies suggest that 5-HT1A and5-HT2A receptors are key players and exert opposite effects on the activity of pyramidal neurons in the medial prefrontal cortex (mPFC).

Dopamine release induced by atypical antipsychotics in prefrontal cortex requires 5-HT(1A) receptors but not 5-HT(2A) receptors.

Results indicate that (1) 5-HT(1A)Rs are necessary for the APD-induced elevation in cortical DA transmission, and (2) this effect does not require 5- HT(2A)R blockade by APDs.

In vivo electrophysiological and neurochemical effects of the selective 5-HT1A receptor agonist, F13640, at pre- and postsynaptic 5-HT1A receptors in the rat

Results indicate that, upon systemic administration, F13640 activates both 5-HT1A autoreceptors and postsynaptic 5- HT1A receptors in prefrontal cortex with a similar potency, likely involved in the analgesic properties of the compound.

Laminar and Cellular Distribution of Monoamine Receptors in Rat Medial Prefrontal Cortex

New data on the quantitative layer distribution of monoamine receptor-expressing cells in the cingulate (Cg), prelimbic (PrL) and infralimbic (IL) subfields of the medial PFC (mPFC) suggest that monoamines may modulate the communications between PFC and cortical/subcortical areas through the activation of receptors expressed by neurons in intermediate and deep layers.

Serotonin 1A receptors in human and monkey prefrontal cortex are mainly expressed in pyramidal neurons and in a GABAergic interneuron subpopulation: implications for schizophrenia and its treatment

The knowledge of the phenotype of the prefrontal cortex (PFC) cells expressing 5‐HT1A will help understanding serotonin actions in PFC.

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Involvement of 5-HT1A Receptors in Prefrontal Cortex in the Modulation of Dopaminergic Activity: Role in Atypical Antipsychotic Action

The results suggest that the activation of mPFC 5-HT1A receptors enhances the activity of VTA DA neurons and mesocortical DA release, which may be involved in the elevation of extracellular DA produced by atypical antipsychotics.

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