Activation of purinergic receptors induces proliferation and neuronal differentiation in Swiss Webster mouse olfactory epithelium.

@article{Jia2009ActivationOP,
  title={Activation of purinergic receptors induces proliferation and neuronal differentiation in Swiss Webster mouse olfactory epithelium.},
  author={Cuihong Jia and Judith P. Doherty and Sean W. Crudgington and Colleen Cosgrove Hegg},
  journal={Neuroscience},
  year={2009},
  volume={163 1},
  pages={120-8}
}
In the central nervous system (CNS), adenosine 5'-triphosphate (ATP) induces the synthesis and release of neurotrophic factors, cell proliferation, and differentiation. The olfactory system is one site where multipotent progenitor cells continue to proliferate and differentiate into neurons throughout life. We tested the hypothesis that ATP initiates proliferation in olfactory epithelium by measuring 5-bromo-2-deoxyuridine incorporation. Adult mice were pre-treated intraperitoneally (i.p.) or… CONTINUE READING
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