Activation of proteinase-activated receptor 1 promotes human colon cancer cell proliferation through epidermal growth factor receptor transactivation.

@article{Darmoul2004ActivationOP,
  title={Activation of proteinase-activated receptor 1 promotes human colon cancer cell proliferation through epidermal growth factor receptor transactivation.},
  author={Dalila Darmoul and Val{\'e}rie Gratio and H{\'e}l{\`e}ne Devaud and Franck Peiretti and Marc Laburthe},
  journal={Molecular cancer research : MCR},
  year={2004},
  volume={2 9},
  pages={514-22}
}
Serine proteases are now considered as crucial contributors to the development of human colon cancer. We have shown recently that thrombin is a potent growth factor for colon cancer cells through activation of the aberrantly expressed protease-activated receptor 1 (PAR1). Here, we analyzed the signaling pathways downstream of PAR1 activation, which lead to colon cancer cell proliferation in HT-29 cells. Our data are consistent with the following cascade of events on activation of PAR1 by… CONTINUE READING

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