Activation of protein-tyrosine phosphatase SH-PTP2 by a tyrosine-based activation motif of a novel brain molecule.

@article{Ohnishi1996ActivationOP,
  title={Activation of protein-tyrosine phosphatase SH-PTP2 by a tyrosine-based activation motif of a novel brain molecule.},
  author={Hidenori Ohnishi and Makoto Kubota and Akira Ohtake and Koichi Sato and Shin ichiro Sano},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 41},
  pages={25569-74}
}
BIT (a brain immunoglobulin-like molecule with tyrosine-based activation motifs) is a brain-specific membrane protein which has two cytoplasmic TAMs (tyrosine-based activation motifs). Using the Far Western blotting technique, we detected association of a 70-kDa protein with the tyrosine-phosphorylated TAMs of BIT. A mouse brain cDNA library in lambdagt11 was screened for this association, and two positive clones encoding tyrosine phosphatase SH-PTP2 were isolated. SH-PTP2 has two SH2 domains… CONTINUE READING
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