Activation of protein kinase D by signaling through Rho and the alpha subunit of the heterotrimeric G protein G13.

@article{Yuan2001ActivationOP,
  title={Activation of protein kinase D by signaling through Rho and the alpha subunit of the heterotrimeric G protein G13.},
  author={Jingzhen Yuan and Lee W Slice and Enrique 4 Rozengurt},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 42},
  pages={38619-27}
}
Protein kinase D (PKD/PKCmu) immunoprecipitated from COS-7 cells transiently transfected with either a constitutively active mutant of Rho (RhoQ63L) or the Rho-specific guanine nucleotide exchange factor pOnco-Lbc (Lbc) exhibited a marked increase in basal activity. Addition of aluminum fluoride to cells co-transfected with PKD and wild type Galpha(13) also induced PKD activation. Co-transfection of Clostridium botulinum C3 toxin blocked activation of PKD by RhoQ63L, Lbc, or aluminum fluoride… CONTINUE READING

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