Activation of protein kinase C is essential for sustained insulin secretion in response to cholinergic stimulation.

@article{Persaud1991ActivationOP,
  title={Activation of protein kinase C is essential for sustained insulin secretion in response to cholinergic stimulation.},
  author={Shanta J Persaud and Peter Martin Jones and Simon James Howell},
  journal={Biochimica et biophysica acta},
  year={1991},
  volume={1091 1},
  pages={120-2}
}
Insulin secretion from isolated rat islets of Langerhans is enhanced by cholinergic agonists, such as carbachol (CCh), in the presence of a stimulatory concentration of glucose. Depletion of islet protein kinase C activity by prolonged exposure to a tumour-promoting phorbol ester did not prevent the initial secretory response to CCh, but markedly reduced the duration of CCh-induced elevated secretory rates. These results suggest that the major action of PKC is in maintaining rather than… CONTINUE READING
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