Activation of protein kinase C by an aromatic xenobiotic diacylglycerol analogue.

@article{Moorhouse1989ActivationOP,
  title={Activation of protein kinase C by an aromatic xenobiotic diacylglycerol analogue.},
  author={K G Moorhouse and D. H. Hutson and Peter F. Dodds},
  journal={FEBS letters},
  year={1989},
  volume={256 1-2},
  pages={43-6}
}
A number of xenobiotic carboxylic acids, including 3-phenoxybenzoic acid (3PBA), have been shown to form 'hybrid' di- and tri-acylglycerols both in vivo and in vitro. Experiments were carried out to test the hypothesis that naturally occurring xenobiotic diacylglycerols may stimulate protein kinase C. The activity of protein kinase C was measured in the presence of different diacylglycerols. 1-Acyl-2-(3PBA)-sn-glycerol but not 1,2-di-3PBA-sn-glycerol stimulated protein kinase C, but less… CONTINUE READING