Activation of protein kinase Cδ leads to increased pancreatic acinar cell dedifferentiation in the absence of MIST1.

@article{Johnson2012ActivationOP,
  title={Activation of protein kinase Cδ leads to increased pancreatic acinar cell dedifferentiation in the absence of MIST1.},
  author={Charis L. Johnson and Jodi M Peat and Sonia N Volante and Rennian Wang and Carolyn A. McLean and Christopher L. Pin},
  journal={The Journal of pathology},
  year={2012},
  volume={228 3},
  pages={351-65}
}
Pancreatic ductal adenocarcinoma (PDAC) has a 5 year survival rate post-diagnosis of < 5%. Individuals with chronic pancreatitis (CP) are 20-fold more likely to develop PDAC, making it a significant risk factor for PDAC. While the relationship for the increased susceptibility to PDAC is unknown, loss of the acinar cell phenotype is common to both… CONTINUE READING