Activation of protein formation and cell division by bradykinin and des-Arg9-bradykinin.

@article{Goldstein1984ActivationOP,
  title={Activation of protein formation and cell division by bradykinin and des-Arg9-bradykinin.},
  author={Ronald H. Goldstein and Michael Wall},
  journal={The Journal of biological chemistry},
  year={1984},
  volume={259 14},
  pages={9263-8}
}
We employed des-Arg9-bradykinin to investigate the relation between bradykinin-induced prostaglandin (PG) synthesis and bradykinin-induced protein accumulation. In this feedback control system, bradykinin-induced PG synthesis limits bradykinin-induced protein production. At low concentration (5 X 10(-8) M), des-Arg9-bradykinin was significantly less active than bradykinin in stimulating the formation of prostaglandins by human fetal lung fibroblasts in culture. At high concentration (5 X 10(-6… CONTINUE READING

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