Activation of protein-bound copper ions during early glycation: study on two proteins.

@article{Argirova2003ActivationOP,
  title={Activation of protein-bound copper ions during early glycation: study on two proteins.},
  author={Mariana D. Argirova and Beryl J. Ortwerth},
  journal={Archives of biochemistry and biophysics},
  year={2003},
  volume={420 1},
  pages={176-84}
}
This study proposes several possible pathways by which hyperglycemia could make protein-bound metal ions more redox active. These mechanisms were tested on bovine serum albumin and calf lens protein. Proteins rich in early glycation products were less capable of competing for copper ions in the presence of other ligands (e.g., glycine and calcein), suggesting that glycated proteins might have diminished stability constants of their copper chelates compared to control counterparts. When protein… CONTINUE READING