Activation of protease-activated receptor1 mediates induction of matrix metalloproteinase-9 by thrombin in rat primary astrocytes

@article{Choi2008ActivationOP,
  title={Activation of protease-activated receptor1 mediates induction of matrix metalloproteinase-9 by thrombin in rat primary astrocytes},
  author={M. Choi and Y. Kim and W. Lee and Ji Woong Choi and Gyu Hwan Park and Sun Don Kim and S. Jeon and Hyo Sang Go and S. Shin and Won-Ki Kim and C. Shin and K. Ko},
  journal={Brain Research Bulletin},
  year={2008},
  volume={76},
  pages={368-375}
}
Thrombin plays an important role in diverse neurological processes such as proliferation, cell migration, differentiation and neuroinflammation. In this study, we investigated the effect of thrombin on matrix metalloprotease-9 (MMP-9) expression in rat primary astrocytes. Thrombin (1-10U/ml) induced a significant increase in MMP-9 activity as measured by gelatin zymography. Thrombin also increased MMP-9 mRNA expression. Among three isotypes of thrombin receptor, i.e. protease-activated receptor… Expand
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  • Medicine
  • The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology
  • 2011
TLDR
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