Activation of proinflammatory caspases by cathepsin B in focal cerebral ischemia.

@article{Benchoua2004ActivationOP,
  title={Activation of proinflammatory caspases by cathepsin B in focal cerebral ischemia.},
  author={Alexandra Benchoua and J{\'e}r{\^o}me Braudeau and Aur{\'e}lia Reis and C{\'e}cile Couriaud and Brigitte Ont{\'e}niente},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2004},
  volume={24 11},
  pages={1272-9}
}
Cathepsins and caspases are two families of proteases that play pivotal roles in ischemic cell death. This study investigated the existence of a cross-talk between cathepsin B and proinflammatory caspases in stroke-induced cell death, as recently suggested by in vitro data. Cortical ischemic damage was induced in mice by distal and permanent occlusion of the middle cerebral artery. Cytoplasmic activation of cathepsin B was observed from the early stages of infarction, and displayed an… CONTINUE READING