Activation of programmed cell death by anticancer agents: cisplatin as a model system.

@article{Eastman1990ActivationOP,
  title={Activation of programmed cell death by anticancer agents: cisplatin as a model system.},
  author={Alan R. Eastman},
  journal={Cancer cells},
  year={1990},
  volume={2 8-9},
  pages={275-80}
}
The anticancer drug cisplatin exerts its action as a consequence of interaction with DNA. Cell cycle progression facilitates sensitivity to the drug, but inhibition of DNA synthesis is not necessarily the critical step. Lethally damaged cells can progress to and arrest for several days in the G2 phase of the cell cycle before dying. Certain features of cisplatin-induced cell death, such as chromatin condensation and the activation of a DNA endonuclease, are reminiscent of apoptosis, or… CONTINUE READING