Activation of potassium channels by tempol in arterial smooth muscle cells from normotensive and deoxycorticosterone acetate-salt hypertensive rats.

@article{Xu2006ActivationOP,
  title={Activation of potassium channels by tempol in arterial smooth muscle cells from normotensive and deoxycorticosterone acetate-salt hypertensive rats.},
  author={Hui Min Xu and William F Jackson and Gregory D. Fink and James J Galligan},
  journal={Hypertension},
  year={2006},
  volume={48 6},
  pages={1080-7}
}
Large-conductance Ca(2+)-activated potassium (BK) channels modulate vascular tone. Tempol, an O(2)(-) dismutase mimetic, causes vasodilation via activation of vascular BK channels. In this study, we investigated the mechanisms underlying tempol-induced activation of BK channels in mesenteric arterial (MA) myocytes from sham and deoxycorticosterone acetate (DOCA)-salt hypertensive rats. In sham myocytes, whole-cell patch clamp studies showed that tempol enhanced peak outward currents (I(o… CONTINUE READING

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