Activation of post-synaptic 5-HT(1A) receptors in the dorsal hippocampus prevents learned helplessness development.

@article{Joca2003ActivationOP,
  title={Activation of post-synaptic 5-HT(1A) receptors in the dorsal hippocampus prevents learned helplessness development.},
  author={S{\^a}mia Regiane Lourenço Joca and Cl{\'a}udia Maria Padovan and Francisco S Guimar{\~a}es},
  journal={Brain research},
  year={2003},
  volume={978 1-2},
  pages={177-84}
}
Activation of post-synaptic 5-HT(1A) receptors in the dorsal hippocampus is proposed to mediate stress adaptation. Chronic social stress and high corticosteroid levels would impair this coping mechanism, predisposing animals to learned helplessness. To test the hypothesis that increasing serotonin levels in the dorsal hippocampus would attenuate the development of learned helplessness, rats received inescapable foot-shock (pre-test session) and were tested in a shuttle box 24-h later. Pre… CONTINUE READING

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