Activation of poly [ADP-Ribose] polymerase in endothelial cells and keratinocytes: role in an in vitro model of sulfur mustard-mediated vesication.

@article{Hinshaw1999ActivationOP,
  title={Activation of poly [ADP-Ribose] polymerase in endothelial cells and keratinocytes: role in an in vitro model of sulfur mustard-mediated vesication.},
  author={Daniel B Hinshaw and Irfan J Lodhi and Laura L. Hurley and Kevin B. Atkins and M I Dabrowska},
  journal={Toxicology and applied pharmacology},
  year={1999},
  volume={156 1},
  pages={17-29}
}
Although endothelial cells and keratinocytes appear to be the primary cellular targets of sulfur mustard (SM), the role of the nuclear enzyme poly (ADP-ribose) polymerase (PARP) in SM-induced vesication has not been clearly defined. PARP is thought to play a crucial role in DNA repair mechanisms following exposure to alkylating agents like SM. Using a combination of fluorescence microscopy and biochemical assays, we tested the hypothesis that SM causes activation of PARP in endothelial cells… CONTINUE READING

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