Activation of platelets in platelet-rich plasma by rotablation is speed-dependent and can be inhibited by abciximab (c7E3 Fab; ReoPro).

@article{Williams1998ActivationOP,
  title={Activation of platelets in platelet-rich plasma by rotablation is speed-dependent and can be inhibited by abciximab (c7E3 Fab; ReoPro).},
  author={Marlene S. Williams and Barry S. Coller and Heikki V{\"a}{\"a}n{\"a}nen and Lesley E Scudder and Samin K. Sharma and Jonathan D. Marmur},
  journal={Circulation},
  year={1998},
  volume={98 8},
  pages={742-8}
}
BACKGROUND Rotational atherectomy with the Rotablator catheter has improved percutaneous treatment of certain coronary atherosclerotic lesions, but the "no-reflow" phenomenon remains a serious complication. Because platelet activation by rotablation may contribute to the no-reflow phenomenon, we developed an in vitro system to test the effect of rotablation on platelets in the absence or presence of platelet GP IIb/IIIa receptor blockade with abciximab. METHODS AND RESULTS Platelet-rich… CONTINUE READING
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