Activation of plasminogen into plasmin at the surface of endothelial microparticles: a mechanism that modulates angiogenic properties of endothelial progenitor cells in vitro.

@article{Lacroix2007ActivationOP,
  title={Activation of plasminogen into plasmin at the surface of endothelial microparticles: a mechanism that modulates angiogenic properties of endothelial progenitor cells in vitro.},
  author={Romaric Lacroix and Florence Sabatier and Agn{\`e}s Mialhe and Agn{\`e}s Basire and Ralph Pannell and H{\'e}l{\`e}ne Borghi and St{\'e}phane Robert and Edouard Lamy and Laurent Plawinski and Laurence Camoin-Jau and Victor Gurewich and Eduardo {\'A}ngles-Cano and Françoise Dignat-George},
  journal={Blood},
  year={2007},
  volume={110 7},
  pages={2432-9}
}
The regulation of plasmin generation on cell surfaces is of critical importance in the control of vascular homeostasis. Cell-derived microparticles participate in the dissemination of biological activities. However, their capacity to promote plasmin generation has not been documented. In this study, we show that endothelial microparticles (EMPs) from tumor necrosis factor alpha (TNFalpha)-stimulated endothelial cells served as a surface for the generation of plasmin. The generation of plasmin… CONTINUE READING