Activation of plasminogen by staphylokinase reduces the severity of Staphylococcus aureus systemic infection.


BACKGROUND Staphylokinase (SAK) is produced by the majority of Staphylococcus aureus strains. It is an extracellular protein that activates the conversion of human plasminogen (plg) to plasmin. The role played by SAK in staphylococcal infection is unclear. METHODS Wild-type S. aureus strain LS-1, which lacks the ability to produce SAK, was modified by an… (More)
DOI: 10.1086/656140


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