Activation of plasmacytoid dendritic cells with TLR9 agonists initiates invariant NKT cell-mediated cross-talk with myeloid dendritic cells.

@article{Montoya2006ActivationOP,
  title={Activation of plasmacytoid dendritic cells with TLR9 agonists initiates invariant NKT cell-mediated cross-talk with myeloid dendritic cells.},
  author={Carlos Julio Montoya and Hyun-Bae Jie and Lena Al-Harthi and Candice B Mulder and Pablo Javier Pati{\~n}o and Mar{\'i}a Teresa Rugeles and Arthur M. Krieg and Alan L. Landay and Sandy Wilson},
  journal={Journal of immunology},
  year={2006},
  volume={177 2},
  pages={1028-39}
}
CD1d-restricted invariant NK T (iNKT) cells and dendritic cells (DCs) have been shown to play crucial roles in various types of immune responses, including TLR9-dependent antiviral responses initiated by plasmacytoid DCs (pDCs). However, the mechanism by which this occurs is enigmatic because TLRs are absent in iNKT cells and human pDCs do not express CD1d. To explore this process, pDCs were activated with CpG oligodeoxyribonucleotides, which stimulated the secretion of several cytokines such… CONTINUE READING

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