Activation of phosphoinositide 3-kinase/PKB pathway by CB(1) and CB(2) cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction.

@article{Snchez2003ActivationOP,
  title={Activation of phosphoinositide 3-kinase/PKB pathway by CB(1) and CB(2) cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction.},
  author={Maria Garc{\'i}a S{\'a}nchez and Lidia Ru{\'i}z-Llorente and Ana M. S{\'a}nchez and In{\'e}s D{\'i}az-Laviada},
  journal={Cellular signalling},
  year={2003},
  volume={15 9},
  pages={
          851-9
        }
}
Cannabinoids exert a variety of physiological and pharmacological responses in humans through interaction with specific cannabinoid receptors. Cannabinoid receptors described to date belong to the seven-transmembrane-domain receptor superfamily and are coupled through the inhibitory G(i) protein to adenylyl cyclase inhibition. However, downstream signal transduction mechanisms triggered by cannabinoids are poorly understood. We examined here the involvement of the phosphoinositide 3-kinase… CONTINUE READING

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