Activation of phosphoinositide/protein kinase C pathway in rat brain tissue by pyrethroids.

@article{Enan1993ActivationOP,
  title={Activation of phosphoinositide/protein kinase C pathway in rat brain tissue by pyrethroids.},
  author={Essam Enan and Fumio Matsumura},
  journal={Biochemical pharmacology},
  year={1993},
  volume={45 3},
  pages={703-10}
}
We have investigated the effects of a type II pyrethroid insecticide, deltamethrin, on changes in the protein phosphorylation pattern associated with neurotransmitter release in rat brain synaptosomal preparations. Deltamethrin was found to stimulate directly the activity of the protein kinase C/phosphoinositide pathway at very low concentrations. This action resulted in an increase in the intracellular concentration of inositol 1,4,5-triphosphate (IP3) and free calcium, as well as an increase… CONTINUE READING
13 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Similar Papers

Loading similar papers…