Activation of phosphodiesterase IV during desensitization of the A2A adenosine receptor-mediated cyclic AMP response in rat pheochromocytoma (PC12) cells.

@article{Chang1997ActivationOP,
  title={Activation of phosphodiesterase IV during desensitization of the A2A adenosine receptor-mediated cyclic AMP response in rat pheochromocytoma (PC12) cells.},
  author={Y. H. Chang and Marco Conti and Ying Chu Lee and Hsing Lin Lai and Yew Ching and Yijuang Chern},
  journal={Journal of neurochemistry},
  year={1997},
  volume={69 3},
  pages={1300-9}
}
Prolonged activation of an A2A adenosine receptor significantly inhibits the cellular response to subsequent stimulation (A2A desensitization). We have reported previously that activation of phosphodiesterase (PDE) contributes to A2A desensitization in PC12 cells. In the present study, we show that a type IV PDE (PDE4)-selective inhibitor (Ro 20-1724) effectively blocks the increase in PDE activity in desensitized cells. Thus, PDE4 appears to be the PDE specifically activated during A2A… CONTINUE READING