Activation of phosphatidylinositol-specific phospholipase C toward inositol 1,2-(cyclic)-phosphate.

Abstract

Phosphatidylinositol-specific phospholipase C (PI-PLC) from Bacillus thuringiensis catalyzes the hydrolysis of phosphatidylinositol (PI) in discrete steps: (i) an intramolecular phosphotransferase reaction to form inositol 1,2-(cyclic)-phosphate (cIP), followed by (ii) a cyclic phosphodiesterase activity that converts cIP to inositol 1-phosphate. Water… (More)

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Cite this paper

@article{Zhou1997ActivationOP, title={Activation of phosphatidylinositol-specific phospholipase C toward inositol 1,2-(cyclic)-phosphate.}, author={C. Zhou and Y. Wu and Mark Roberts}, journal={Biochemistry}, year={1997}, volume={36 2}, pages={347-55} }