Activation of phosphatidylinositol 3-kinase/Akt pathway by androgen through interaction of p85alpha, androgen receptor, and Src.

@article{Sun2003ActivationOP,
  title={Activation of phosphatidylinositol 3-kinase/Akt pathway by androgen through interaction of p85alpha, androgen receptor, and Src.},
  author={Mei Sun and Lin Yang and Richard I. Feldman and Xia-meng Sun and Kapil N. Bhalla and Richard Jove and Santo V. Nicosia and Jin Quan Cheng},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 44},
  pages={42992-3000}
}
Recent studies have demonstrated that the cell growth and antiapoptotic actions of androgen could be dissociated from the transcriptional activity of the receptor and were, instead, mediated by activation of a mitogen-activated protein kinase pathway. This finding suggests an important cellular function of androgen receptor (AR) outside the nucleus. In this report, we demonstrate that androgen activates phosphatidylinositol 3-kinase (PI3K) and Akt, including AKT1 and AKT2, in AR-positive cells… CONTINUE READING

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