Activation of peroxisome proliferator-activated receptor δ inhibits angiotensin II-induced activation of matrix metalloproteinase-2 in vascular smooth muscle cells.

Abstract

We investigated the role of peroxisome proliferator-activated receptor (PPAR) δ on angiotensin (Ang) II-induced activation of matrix metalloproteinase (MMP)-2 in vascular smooth muscle cells (VSMCs). Activation of PPARδ by GW501516, a specific ligand for PPARδ, attenuated Ang II-induced activation of MMP-2 in a concentration-dependent manner. GW501516 also… (More)
DOI: 10.1159/000365250

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Cite this paper

@article{Ham2014ActivationOP, title={Activation of peroxisome proliferator-activated receptor δ inhibits angiotensin II-induced activation of matrix metalloproteinase-2 in vascular smooth muscle cells.}, author={Sun Ah Ham and Hanna Lee and Jung Seok Hwang and Eun Sil Kang and Taesik Yoo and Kyung Shin Paek and Jeong Tae Do and Chankyu Park and Jae-Wook Oh and Jin-Hoi Kim and Chang Woo Han and Han Geuk Seo}, journal={Journal of vascular research}, year={2014}, volume={51 3}, pages={221-30} }