Activation of peroxisome proliferator-activated receptor-gamma in dendritic cells inhibits the development of eosinophilic airway inflammation in a mouse model of asthma.

@article{Hammad2004ActivationOP,
  title={Activation of peroxisome proliferator-activated receptor-gamma in dendritic cells inhibits the development of eosinophilic airway inflammation in a mouse model of asthma.},
  author={Hamida Hammad and Hendrik Jan de Heer and Thomas Soulli{\'e} and Veronique Angeli and François Trottein and Henk C. Hoogsteden and Bart M. Lambrecht},
  journal={The American journal of pathology},
  year={2004},
  volume={164 1},
  pages={263-71}
}
Peroxisome proliferator-activated receptors (PPARs) are activated by an array of polyunsaturated fatty acid derivatives, oxidized fatty acids, and phospholipids and are proposed to be important modulators of immune and inflammatory responses. Recently, we showed that activation of PPAR-gamma alters the maturation process of dendritic cells (DCs), the most potent antigen-presenting cells. In the present report, we investigated the possibility that, by targeting DCs, PPAR-gamma activation may be… CONTINUE READING